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Document ID (ISN)108223
CIS number 08-667
ISSN - Serial title 1877-7856 - Encyclopédie médico-chirurgicale
Year 2007
Convention or series no. Fascicule 16002 F 10, 1-2007
Author(s) Flesch F., Tournoud C., Thaon I., Benhassine E.
Title Iron poisoning
Original title Intoxications par le fer [in French]
Bibliographic information Toxicologie-Pathologie professionnelle, 1st Quarter 2007, No.154, 6p. 53 ref.
Internet access 08-0667.pdf [in French]
Abstract Most acute intoxications caused by iron are the result of ferrous salt ingestion, either accidentally in children or more rarely in suicidal attempts among adults. The main toxic mechanism of iron is related to its capacity to induce the formation of free radicals, followed by lipid peroxidation. Classically, five clinical phases have been identified: gastrointestinal toxicity; transitory relative stability; systemic toxicity with shock, metabolic acidosis and coma; hepatotoxicity with coagulopathy; gastrointestinal scarring. Therapy includes supportive care, whole bowel irrigation and the use of deferoxamine, a specific iron chelator. Activated charcoal is ineffective. Chronic exposure to iron occurs primarily in occupational settings and causes pneumoconiosis following the inhalation of dust and iron oxides. Ocular siderosis is a chronic disease that may lead to a vision loss. It occurs when a particle containing iron penetrates in the eye.
Descriptors (primary) poisoning; iron and compounds; iron; risk factors; France; toxicology; occupational diseases
Descriptors (secondary) literature survey; children; acute poisoning; deferoxamine; ingestion; pneumoconiosis; data sheet; siderosis; suicide; chronic poisoning; medical treatment; encyclopaedia; gastrointestinal diseases
Document type F - Information notes, codes of practice, standards
Country / State or ProvinceFrance
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Iron and compounds
Inorganic substances