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CISDOC database

Document ID (ISN)107902
CIS number 08-404
ISSN - Serial title 1351-0711 - Occupational and Environmental Medicine
Year 2007
Convention or series no.
Author(s) Bowler R.M., Roels H.A., Nakagawa S., Drezgic M., Diamond E., Park R., Koller W., Bowler R.P., Mergler D., Bouchard M., Smith D., Gwiazda R., Doty R.L.
Title Dose-effect relationships between manganese exposure and neurological, neuropsychological and pulmonary function in confined space bridge workers
Bibliographic information Mar. 2007, Vol.64, No.3, p.167-177. Illus. 45 ref.
Internet access 08-0404.pdf [in English]
Abstract This study involved 43 welders exposed to welding fumes containing manganese during the construction of a bridge span, who were administered neurological, neuropsychological, neurophysiological and pulmonary tests. Various outcomes were analysed in relation to blood manganese (MnB) and an estimated cumulative exposure index (CEI). The time weighted average of manganese in air ranged from 0.11-0.46mg/m3. MnB levels of more than 10µg/L were found in 43% of the workers. Lung function values were found to be below normal in 33.3% of the welders. Computer assisted tremor analysis tests, body sway tests and smell identification tests showed impairment in 38.5 to 88% of the welders. Significant inverse dose-effect relationships with CEI and/or MnB were found for IQ, executive function, sustaining concentration and sequencing, verbal learning, working and immediate memory. Dose-effect associations between CEI and sexual function, fatigue, depression and headache reported by the workers were significant. Other findings are discussed.
Descriptors (primary) neurotoxic effects; manganese and compounds; manganese; welding and cutting; welding fumes; construction industry; dose-response relationship; USA
Descriptors (secondary) tremor; determination in blood; subjective assessment; cognitive performance; sexual disorders; migraine; depressive neurosis; disturbances of memory; work in confined spaces; short-time memory; fatigue; mental health; intelligence; exposure evaluation; breathing atmosphere; neuropsychic effects; respiratory function tests; determination in air; nervous function tests
Document type D - Periodical articles
Country / State or ProvinceCanada; USA
Subject(s) Construction industry
Metal production and metalworking
Broad subject area(s) Chemical safety
Occupational medicine, epidemiology
Browse category(ies) Diseases of the nervous system
Construction industry and civil engineering
Welding and cutting
Inorganic substances