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Document ID (ISN)107675
CIS number 08-164
ISSN - Serial title 0105-1873 - Contact Dermatitis
Year 2007
Convention or series no.
Author(s) Laukkanen A., Ruoppi P., Remes S., Koistinen T., Mńkinen-Kiljunen S.
Title Lactase-induced occupational protein contact dermatitis and allergic rhinoconjunctivitis
Bibliographic information Aug. 2007, Vol.57, No.2, p.89-93. Illus. 19 ref.
Abstract This article reports a case of protein contact dermatitis and allergic rhinoconjunctivitis from occupational exposure to lactase in a female pharmaceutical worker in Finland. The patient exhibited strong positive responses to lactase in prick tests. In an open application test, lactase elicited whealing, and in patch testing, lactase elicited an eczematous reaction. Serum lactase-specific immunoglobulin E (IgE) antibodies were demonstrated in immunospot and radioallergosorbent test assays, and lactase-IgE-binding fractions were examined in immunoblot and immunoblot inhibition assays. The chamber challenge test was performed to detect the association between lactase sensitization and rhinoconjunctival symptoms. The results confirm previous observations that lactase can induce occupational IgE- mediated respiratory and conjunctival sensitizations, but in addition show that contact skin reactions caused by lactase may also occur.
Descriptors (primary) allergens; rhinitis; pharmaceutical industry; skin diseases; conjunctivitis; enzymes
Descriptors (secondary) irritants; immunoglobulins; case study; Finland; symptoms; sensitization; skin eruption; urticaria; allergy tests; skin tests; eczema
Document type D - Periodical articles
Country / State or ProvinceFinland
Subject(s) Chemicals, plastics and rubber
Broad subject area(s) Chemical safety
Browse category(ies) Diseases of the respiratory system (except for pneumoconiosis & similar)
Pharmaceutical industry
Skin diseases
Diseases of the eye and vision damage