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Document ID (ISN)107551
CIS number 08-162
ISSN - Serial title 0105-1873 - Contact Dermatitis
Year 2007
Convention or series no.
Author(s) Bergendorff O., Persson C., LŘdtke A, Hansson C.
Title Chemical changes in rubber allergens during vulcanization
Bibliographic information Sep. 2007, Vol.57, No.3, p.152-157. Illus. 13 ref.
Abstract Vulcanization accelerators such as thiurams, dithiocarbamates and mercaptobenzothiazoles are among the rubber additives often responsible for allergic reactions recognized by dermatologists. The chemistry of the vulcanization process is complicated; as it occurs at an elevated temperature with a mixture of reactive chemicals. This study investigated the changes in composition of common allergens during vulcanization at different stages of the process. Major changes were found in which added chemicals were consumed and new ones produced. An important observation is that thiuram disulfides rarely appear in the final rubber even when used as additives. Instead, thiurams are often converted to dithiocarbamates or to products formed by addition to mercaptobenzothiazoles, if these have been used together with thiurams as accelerators. In conclusion, an assessment of exposure to allergens should not be based solely on knowledge concerning the additives used, but also on the chemical analysis of products formed during the vulcanization reaction.
Descriptors (primary) allergens; mercaptans; benzothiazolethiol; thioamides; chemical reactions; rubber chemicals; vulcanizing agents; dithiocarbamates
Descriptors (secondary) vulcanization; high-pressure liquid chromatography; sampling and analysis; exposure evaluation
Document type D - Periodical articles
Country / State or ProvinceSweden
Subject(s) Chemicals, plastics and rubber
Broad subject area(s) Chemical safety
Browse category(ies) Amides
Organosulfur compounds
Heterocyclic compounds