| Document ID (ISN) | 107464 |
| CIS number |
07-1253 |
| ISBN(s) |
978-3-7776-1531-8 |
| Year |
2007 |
| Convention or series no. |
BUA Report 265
|
| Author(s) |
Advisory Committee on Existing Chemicals (BUA) |
| Title |
2-Chlorobenzonitrile; 4-chlorobenzonitrile |
| Bibliographic information |
S. Hirzel Verlag, Birkenwaldstrasse 44, 70191 Stuttgart, Germany, 2007. xiv, 48p. 121 ref. Price: EUR 00.00. Downloadable version free of charge. |
| Internet access |
http://www.dav-buchhandlung.de/... [in English]
|
| Abstract |
Conclusions of this criteria document which reflects the state of knowledge of April 2006: the toxicity of 2-chlorobenzonitrile and 4-chlorobenzonitrile are low. In rats, the oral LD5l0 for 2-chlorobenzonitrile and 4-chlorobenzonitrile are 396mg and 887mg per kg body weight respectively. For 2-chlorobenzonitrile, the 4h LC50 in rats is more than 440mg/m3 and the dermal LD5l0 in rabbits is between 340 and 600 mg/kg body weight. No corresponding data are available for 4-chlorobenzonitrile. In mutagenicity tests, 2-chlorobenzonitrile is non-mutagenic up to the cytotoxic range. No data on mutagenicity are available for 4-chlorobenzonitrile. No data for either substance are available for an evaluation of the sensitization potential, genotoxicity, carcinogenicity and reproductive toxicity. |
| Descriptors (primary) |
toxic effects; Germany; ecotoxicology; nitriles; chlorinated organic compounds |
| Descriptors (secondary) |
literature survey; criteria document; animal experiments |
| Document type |
B - Chemical safety information sheets |
| Country / State or Province | Germany |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
|
| Browse category(ies) |
Pollution control
Cyano compounds
|
