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Document ID (ISN)107429
CIS number 07-1372
ISSN - Serial title 1545-9624 - Journal of Occupational and Environmental Hygiene
Year 2007
Convention or series no.
Author(s) Fustinoni S., Mercadante R., Campo L., Scibetta L., Valla C., Consonni D., Foà V.
Title Comparison between urinary o-cresol and toluene as biomarkers of toluene exposure
Bibliographic information Jan. 2007, Vol.4, No.1, p.1-9. Illus. 31 ref.
Abstract This case-control study compared urinary o-cresol (U-OC) and urinary toluene (U-TOL) as biomarkers of occupational exposure to toluene. One hundred healthy male rotogravure printing workers and 161 male and female control subjects unexposed to toluene were studied. Personal exposure to airborne toluene (TOL-A) during the shift was determined as a time weighted average. Simple analytical procedures based on solid phase micro-extraction followed by gas chromatography-mass spectrometry analysis were applied to the determination of end-shift U-OC and U-TOL. Median TOL-A was 48mg/m3 in printers and 0.021mg/m3 in controls. U-OC was 0.185mg/g creatinine in printers and 0.027mg/g in controls. U-TOL was 7.6µg/L in printers and 0.140µg/L in controls. U-TOL was found to be a slightly more reliable biomarker to toluene exposure than U-OC.
Descriptors (primary) o-cresol; exposure tests; toluene
Descriptors (secondary) personal sampling; reliability; case-control study; comparative study; sampling and analysis; determination in air; determination in urine; breathing atmosphere
Document type D - Periodical articles
Country / State or ProvinceItaly
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Biological monitoring
Aromatic hydrocarbons