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Document ID (ISN)106935
CIS number 07-881
ISSN - Serial title 0340-0131 - International Archives of Occupational and Environmental Health
Year 2006
Convention or series no.
Author(s) Wu M.T., et al.
Title Sperm DNA damage correlates with polycyclic aromatic hydrocarbons biomarker in coke-oven workers
Bibliographic information May 2006, Vol.79, No.5, p.349-356. Illus. 41 ref.
Internet access http://www.springerlink.com/content/fx70q8u68g494803/fulltext.pdf [in English]
Abstract The aim of this study was to determine whether occupational exposure to polycyclic aromatic hydrocarbons (PAHs) in men has an adverse effect on semen quality. Forty-eight coke-oven workers, including 16 topside-oven workers and 32 side-oven workers, were studied. Ambient PAHs exposure, urinary 1-hydroxypyrene (1-OHP) levels and parameters of semen quality were determined. Findings are discussed. A potential risk of sperm dysfunction should be considered for workers occupationally exposed to high levels of PAHs. Cigarette smoking may aggravate this risk. Urinary 1-OHP was found to be a useful a biomarker for predicting sperm dysfunction.
Descriptors (primary) aromatic hydrocarbons; polycyclic hydrocarbons; spermatogenic disturbances; coke ovens
Descriptors (secondary) Taiwan (China); DNA; smoking; determination in urine; genetic effects; determination in air; 1-hydroxypyrene
Document type D - Periodical articles
Country / State or ProvinceTaiwan (China)
Subject(s) Metal production and metalworking
Broad subject area(s) Chemical safety
Browse category(ies) Diseases of the reproductive system
Polycyclic hydrocarbons
Aromatic hydrocarbons
Genetic factors in reaction to exposures