|Document ID (ISN)||106925|
|ISSN - Serial title
||1076-2752 - Journal of Occupational and Environmental Medicine
|Convention or series no.
||Garšon G., Leleu B., Zerimech F., Marez T., Haguenoer J.M., Furon D., Shirali P.
||Biologic markers of oxidative stress and nephrotoxicity as studied in biomonitoring of adverse effects of occupational exposure to lead and cadmium
||Nov. 2004, Vol.46, No.11, p.1180-1186. 35 ref.
||07-0866.pdf [in English]
||This study examined the impregnation levels of workers occupationally exposed to lead and cadmium, the usefulness of early urinary markers of nephrotoxicity and the occurrence of oxidative stress as the underlying mechanism involved in adverse effects induced by lead or cadmium. Levels of lead and cadmium in blood and urine were measured in 35 male workers in a nonferrous metal smelter. Relations between oxidative stress markers and exposure levels, on the one hand, and early urinary markers and exposure levels, on the other hand, were evaluated. Mean exposure levels were moderate. Findings suggest the use of α-glutathione S-transferases excretion in urine as an indicator of early changes in the proximal tubular integrity that could later lead to clinical disease if exposure is not reduced.
||cadmium and compounds; lead and compounds; smelting plants; exposure tests; nephrotoxic effects
||male workers; lead; transferases; determination in urine; determination in blood; cadmium; urinary excretion
||D - Periodical articles
|Country / State or Province||France|
||Toxic and dangerous substances
|Broad subject area(s)
Smelting and refining operations
Lead and compounds
Cadmium and compounds