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Document ID (ISN)106925
CIS number 07-866
ISSN - Serial title 1076-2752 - Journal of Occupational and Environmental Medicine
Year 2004
Convention or series no.
Author(s) Garšon G., Leleu B., Zerimech F., Marez T., Haguenoer J.M., Furon D., Shirali P.
Title Biologic markers of oxidative stress and nephrotoxicity as studied in biomonitoring of adverse effects of occupational exposure to lead and cadmium
Bibliographic information Nov. 2004, Vol.46, No.11, p.1180-1186. 35 ref.
Abstract This study examined the impregnation levels of workers occupationally exposed to lead and cadmium, the usefulness of early urinary markers of nephrotoxicity and the occurrence of oxidative stress as the underlying mechanism involved in adverse effects induced by lead or cadmium. Levels of lead and cadmium in blood and urine were measured in 35 male workers in a nonferrous metal smelter. Relations between oxidative stress markers and exposure levels, on the one hand, and early urinary markers and exposure levels, on the other hand, were evaluated. Mean exposure levels were moderate. Findings suggest the use of α-glutathione S-transferases excretion in urine as an indicator of early changes in the proximal tubular integrity that could later lead to clinical disease if exposure is not reduced.
Descriptors (primary) cadmium and compounds; lead and compounds; smelting plants; exposure tests; nephrotoxic effects
Descriptors (secondary) male workers; lead; transferases; determination in urine; determination in blood; cadmium; urinary excretion
Document type D - Periodical articles
Country / State or ProvinceFrance
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Inorganic substances
Cadmium and compounds
Biological monitoring
Smelting and refining operations
Lead and compounds