| Document ID (ISN) | 106918 |
| CIS number |
07-865 |
| ISSN - Serial title |
0340-0131 - International Archives of Occupational and Environmental Health |
| Year |
2004 |
| Convention or series no. |
|
| Author(s) |
Kezic S., Meuling W.J.A., Jakasa I. |
| Title |
Free and total urinary 2-butoxyacetic acid following dermal and inhalation exposure to 2-butoxyethanol in human volunteers |
| Bibliographic information |
Nov. 2004, Vol.77, No.8, p.580-586. Illus. 18 ref. |
| Internet access |
http://www.springerlink.com/content/1hnb9mtxtl85d5hx/fulltext.pdf [in English]
|
| Abstract |
To assess excretion kinetics of free and total 2-butoxyacetic acid (BAA) following dermal and inhalation exposure to 2-butoxyethanol (BE), six male volunteers were dermally-exposed for 4h to a 50% aqueous BE on the forearm. Six other male volunteers were exposed by inhalation (mouth only) to 93mg/m3 BE for 30min. As biological indices of exposure, BE in blood and total and free BAA in urine were measured. Findings are discussed. Overall, inter-individual variability was large. However, due to lower inter-individual variability, total BAA was found to be superior to free BAA as a biomarker of both cutaneous and inhalation exposures to BE. |
| Descriptors (primary) |
butoxyethanol; exposure tests; butoxyacetic acid |
| Descriptors (secondary) |
inhalation; skin absorption; determination in urine; human experiments; determination in blood; exposure evaluation |
| Document type |
D - Periodical articles |
| Country / State or Province | Netherlands |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
Chemical safety
|
| Browse category(ies) |
Biological monitoring
Glycol ethers
|
