|Document ID (ISN)||106813|
|ISSN - Serial title
||0160-2748 - Neurotoxicology
|Convention or series no.
||Chia S.E., Yap E., Chia K.S.
||δ-Aminolevulinic acid dehydratase (ALAD) polymorphism and susceptibility of workers exposed to inorganic lead and its effects on neurobehavioral functions
||2004, Vol.25, p.1041-1047. 20 ref.
||07-0856.pdf [in English]
||This cross-sectional study was carried out to determine the frequency of δ-aminolevulinic acid dehydratase (ALAD) polymorphisms among a total of 120 ethnic Chinese, Malay and Indian male workers who were exposed to low to medium levels of inorganic lead. The association between ALAD1 and ALAD2 genotypes and neurobehavioural functions among these workers was also investigated. Blood and urine were collected to determine the ALAD genotypes, blood lead levels, ALAD, and urinary δ-aminolevulinic acid (ALA). ALAD1-1 was the predominant genotype for all three ethnic groups while ALAD2-2 was the rarest. The distribution of ALAD1-2 was higher among Malays (76.7%) and Indians (14.3%), compared to Chinese (3.6%). Workers with ALAD1-1 genotypes had significantly higher urinary ALA and significantly poorer neurobehavioral scores than those with ALAD1-2/2-2 genotypes. The ALAD2 allele may exert protective measures against the neurotoxic effects of lead.
||neurotoxic effects; individual susceptibility; ALAD; lead and compounds
||race-linked differences; airborne dust; nervous function tests; Singapore; determination in urine; lead oxide; aminolevulinic acid; cross-sectional study; determination in blood; lead
||D - Periodical articles
|Country / State or Province||Singapore|
||Toxic and dangerous substances
|Broad subject area(s)
Diseases of the nervous system
Lead and compounds