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Document ID (ISN)106739
CIS number 07-649
ISSN - Serial title 0105-1873 - Contact Dermatitis
Year 2006
Convention or series no.
Author(s) Madan V., Beck M.H.
Title Occupational allergic contact dermatitis from N,N-methylene-bis-5-methyl-oxazolidine in coolant oils
Bibliographic information July 2006, Vol.55, No.1, p.39-41. 10 ref.
Abstract Contact with metal working fluids (MWF) is an important factor in the development of occupational hand dermatitis in patients working in the metal processing industry. Biocides are added to MWF as preservatives and are known sensitizers. This study analysed 318 patch test reactions to N,N-methylene-bis-5-methyl-oxazolidine 1% in petrolatum present in coolant oils in patients exposed to MWF and with suspected occupational dermatitis. Positive allergic reactions were noted in 15 cases. In seven cases, it was possible to confirm the presence of N,N-methylene-bis-5-methyl-oxazolidine in the oils used by the patients. Positive reactions to formaldehyde were seen in 11 patients. Sensitization to N,N-methylene-bis-5-methyl-oxazolidine and/or formaldehyde allergy was considered likely to have contributed to the workers' dermatitis.
Descriptors (primary) allergens; 3,3'-methylene-bis(5-methyloxazolidine); metalworking industry; skin diseases; cutting fluids; biocides
Descriptors (secondary) formaldehyde; sensitization; skin tests; eczema
Document type D - Periodical articles
Country / State or ProvinceUnited Kingdom
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Skin diseases
Heterocyclic compounds
Metalworking industry