| Document ID (ISN) | 106558 |
| CIS number |
07-508 |
| ISBN(s) |
978-92-4-153069-9 |
| Year |
2006 |
| Convention or series no. |
CICAD No.69
|
| Author(s) |
Kim J.H., Gibb H.J., Howe P.D.
Inter-Organization Programme for the Sound Management of Chemicals (IOMC) |
| Title |
Cobalt and inorganic cobalt compounds |
| Bibliographic information |
World Health Organization, Distribution and Sales Service, 1211 Genève 27, Switzerland, 2006. iv, 88p. Illus. Approx. 450 ref. |
| Internet access |
http://www.who.int/ipcs/publications/cicad/cicad69%20.pdf [in English]
|
| Abstract |
Conclusions of this criteria document on cobalt and inorganic cobalt compounds: rats and mice exposed to cobalt salts by ingestion exhibited a number of effects including necrosis and inflammation of the respiratory tract epithelium, cardiac damage, testicular atrophy and kidney damage. Lung tumours were found in rats and mice exposed to cobalt oxide fumes. Many cobalt salts are genotoxic to mammals. Cobalt has been found to have reproductive and developmental effects in animals. There are reports of skin sensitization in humans following dermal exposure. There is an excess of cancer deaths among workers in the hard metal industry, but the role of cobalt as opposed to other substances has not been proven. An inhalation tolerable concentration of 0.1µg/m3 has been derived based on a cross-sectional study of lung function decrement among diamond polishers. Detailed summaries in French and Spanish are included. |
| Descriptors (primary) |
cobalt and compounds; toxicology; IPCS |
| Descriptors (secondary) |
toxic effects; sensitization; literature survey; threshold limit values; cobalt; cobalt (II,III) oxide; cobaltous sulfate; ILO; WHO; irritation; alloys; diamond cutting; heart diseases; cross-sectional study; ecotoxicology; animal experiments; carcinogenic effects; criteria document; embryotoxic effects |
| Document type |
B - Chemical safety information sheets |
| Country / State or Province | WHO |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
Chemical safety
|
| Browse category(ies) |
Inorganic substances
|
