| Document ID (ISN) | 106555 |
| CIS number |
07-505 |
| ISBN(s) |
92-4-153067-7 |
| Year |
2005 |
| Convention or series no. |
CICAD No.67
|
| Author(s) |
Copestake P.
Inter-Organization Programme for the Sound Management of Chemicals (IOMC) |
| Title |
Selected alkoxyethanols - 2-Butoxyethanol |
| Bibliographic information |
World Health Organization, Distribution and Sales Service, 1211 Genève 27, Switzerland, 2005. iv, 51p. Illus. Approx. 180 ref. |
| Internet access |
http://www.who.int/entity/ipcs/publications/cicad/cicad_67_2_butoxyethanol.pdf [in English]
|
| Abstract |
This criteria document on 2-butoxyethanol is an update of the earlier edition published in 1998 (see CIS 04-262). Human health aspects have been extensively revised on the basis of recent data on carcinogenicity and modes of action. 2-Butoxyethanol has moderate acute toxicity and is irritating to the eyes and skin; it is not a skin sensitizer. The main effect exerted by 2-butoxyethanol and its metabolite 2-butoxyacetic acid is haematotoxicity, with the rat being the most sensitive species. In animals, adverse effects on reproduction and development have not been observed at less than toxic doses. Long-term studies in laboratory animals show some evidence of carcinogenicity in mice. Based on the haemolytic effects observed on pregnant rats exposed during gestation, a revised tolerable concentration of 11.0mg/m3 has been derived. Detailed summaries in French and Spanish are included. |
| Descriptors (primary) |
toxic effects; toxicology; butoxyethanol; IPCS |
| Descriptors (secondary) |
literature survey; threshold limit values; irritants; ILO; UNEP; WHO; criteria document; ecotoxicology; animal experiments; in vitro experiments; haematotoxic effects; carcinogenic effects; butoxyacetic acid |
| Document type |
B - Chemical safety information sheets |
| Country / State or Province | WHO |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
Chemical safety
|
| Browse category(ies) |
Glycol ethers
|
