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Document ID (ISN)106398
CIS number 07-397
ISSN - Serial title 0340-0131 - International Archives of Occupational and Environmental Health
Year 2006
Convention or series no.
Author(s) van Thriel C., et al.
Title From chemosensory thresholds to whole-body exposures - Experimental approaches for evaluating chemosensory effects of chemicals
Bibliographic information Apr. 2006, Vol.79, No.4, p.308-321. Illus. 44 ref.
Abstract The avoidance of adverse chemosensory effects is essential at workplaces where volatile chemicals are used. In the first part of this study, the odour (OT) and irritation thresholds (IT) of 15 irritants were determined in a random sample of 144 persons stratified for gender and age. Irritants exhibiting high chemosensory potency were selected for the second psychophysical part of the study, where 48 persons, again stratified for gender and age, rated the intensity of 13 trigeminal and olfactory perceptions elicited by nine ascending concentrations of the irritants. Across the investigated chemicals, the transition from concentrations eliciting pure olfactory stimulation (OT) to trigeminal stimulation (IT) differed markedly. Gender and age had only weak impact on the chemosensory thresholds.
Descriptors (primary) irritation; volatile substances; olfactometry; olfaction; chemical products
Descriptors (secondary) subjective assessment; odour threshold; individual susceptibility; evaluation of technique; exposure evaluation
Document type D - Periodical articles
Country / State or ProvinceGermany
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Diseases of other sense organs (other than the eye and the ears)