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Document ID (ISN)106365
CIS number 07-387
ISSN - Serial title 0105-1873 - Contact Dermatitis
Year 2006
Convention or series no.
Author(s) Thyssen J.P., Sederberg-Olsen N., Thomsen J.F., MennÚ T.
Title Contact dermatitis from methylisothiazolinone in a paint factory
Bibliographic information June 2006, Vol.54, No.6, p.322-324. 16 ref.
Abstract The introduction of new potential contact-sensitizing chemicals have in the past led to epidemics of contact dermatitis. A new preservative containing only methyl-isothiazolinone (MI) and not methyl-chloroisothiazolinone (MCI) has recently been introduced for use in products such as paint, glue and cosmetics. This article describes an outbreak of contact allergy to MI and MCI among four out of 14 workers in a paint factory. Patch test results from all four patients showed positive reactions for MI and MCI/MI. The reactions were stronger for MI than MCI/MI indicating a primary sensitization to MI. The combination of MCI/MI remains widely used, and therefore various patterns of exposure and sensitization may be seen in the future. The data show that MI holds a potential for eliciting and probably inducing contact allergy in humans.
Descriptors (primary) allergens; paint and varnish industry; skin diseases; biocides; isothiazolinones
Descriptors (secondary) 2-methyl-2,3-dihydroisothiazol-3-one; case study; 5-chloro-2-methyl-2,3-dihydroisothiazol-3-one; sensitization; eczema; allergy tests; skin tests; cosmetics
Document type D - Periodical articles
Country / State or ProvinceDenmark
Subject(s) Chemicals, plastics and rubber
Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Chemical industry
Skin diseases
Heterocyclic compounds