ILO Home
Go to the home page
Site map | Contact us Franšais | Espa˝ol

CISDOC database

Document ID (ISN)106298
CIS number 07-377
ISSN - Serial title 1080-3548 - International Journal of Occupational Safety and Ergonomics
Year 2006
Convention or series no.
Author(s) Kupczewska-Dobecka M., Soćko R., Czerczak S.
Title RD50 as the criterion for setting maximum admissible levels of occupational exposure to irritants in Poland
Bibliographic information 1st quarter 2006, Vol.12, No.1, p.95-99. 17 ref.
Abstract The aim of this project was to analyse Maximum Admissible Concentration (MAC) values that were proposed for irritants by the Group of Experts for Chemical Agents in Poland, based on the RD50 values (concentrations which elicits a 50% decrease in respiratory rate). Between 1994 and 2004, MAC values for irritants based on RD50 values were set for 17 chemicals. The determined MAC values were found to be within 0.01-0.09 of the RD50 values. The RD50 value was found to be a good rough criterion to set MAC values for irritants, making it possible to make a quick estimation of permissible exposure levels. However, simply setting the MAC value for an irritant at the level of 0.03 RD50 is insufficient to determine precisely the possible hazard to workers' health. Other available toxicological data, such as NOAEL (No Observed Adverse Effect Level) and LOAEL (Lowest Observed Adverse Effect Level) should always be considered as well.
Descriptors (primary) irritants; determination of exposure limits; permissible levels; Poland
Descriptors (secondary) threshold limit values; description of technique; exposure evaluation
Document type D - Periodical articles
Country / State or ProvincePoland
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Occupational exposure limits