|Document ID (ISN)||106298|
|ISSN - Serial title
||1080-3548 - International Journal of Occupational Safety and Ergonomics
|Convention or series no.
||Kupczewska-Dobecka M., Soćko R., Czerczak S.
||RD50 as the criterion for setting maximum admissible levels of occupational exposure to irritants in Poland
||1st quarter 2006, Vol.12, No.1, p.95-99. 17 ref.
||The aim of this project was to analyse Maximum Admissible Concentration (MAC) values that were proposed for irritants by the Group of Experts for Chemical Agents in Poland, based on the RD50 values (concentrations which elicits a 50% decrease in respiratory rate). Between 1994 and 2004, MAC values for irritants based on RD50 values were set for 17 chemicals. The determined MAC values were found to be within 0.01-0.09 of the RD50 values. The RD50 value was found to be a good rough criterion to set MAC values for irritants, making it possible to make a quick estimation of permissible exposure levels. However, simply setting the MAC value for an irritant at the level of 0.03 RD50 is insufficient to determine precisely the possible hazard to workers' health. Other available toxicological data, such as NOAEL (No Observed Adverse Effect Level) and LOAEL (Lowest Observed Adverse Effect Level) should always be considered as well.
||irritants; determination of exposure limits; permissible levels; Poland
||threshold limit values; description of technique; exposure evaluation
||D - Periodical articles
|Country / State or Province||Poland|
||Toxic and dangerous substances
|Broad subject area(s)
||Occupational exposure limits