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CISDOC database

Document ID (ISN)106285
CIS number 07-373
ISSN - Serial title 0340-0131 - International Archives of Occupational and Environmental Health
Year 2006
Convention or series no.
Author(s) Lawton B.W., Hoffmann J., Triebig G.
Title The ototoxicity of styrene: A review of occupational investigations
Bibliographic information Feb. 2006, Vol.79, No.2, p.93-102. Illus. 23 ref.
Abstract Seven occupational studies dealing with the ototoxicity of styrene were analysed. Factors assessed included the experimental design, measurement of the styrene-in-air concentration, confirmation of styrene exposure by blood or urine analysis, determination of hearing threshold levels and measurement of noise at the workplace. Findings are equivocal. Four investigations failed to find any effect of styrene on hearing thresholds. In contrast, other investigations claimed to have demonstrated styrene-induced hearing loss in industrial populations, with synergism between styrene and noise. However, these reports exhibited shortcomings of experimental design and data analysis. Considering the body of evidence as a whole, hearing deficits due to occupational exposure to styrene at low concentrations have not been demonstrated by scientifically reliable argument.
Descriptors (primary) styrene; ototoxic effects; hearing loss
Descriptors (secondary) literature survey; exposure evaluation; epidemiologic study; determination in urine; synergism; determination in blood; hearing threshold
Document type D - Periodical articles
Country / State or ProvinceGermany; United Kingdom
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Aromatic hydrocarbons
Diseases of the ear and hearing damage