| Document ID (ISN) | 105879 |
| CIS number |
06-1264 |
| Year |
2005 |
| Convention or series no. |
ECETOC JACC No.49
|
| Author(s) |
Gribble M. |
| Title |
Vinylidene fluoride (CAS No. 75-38-7) |
| Bibliographic information |
European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC), Avenue E. Van Nieuwenhuyse 4, Bte. 6, 1160 Bruxelles, Belgium, Nov. 2005. 54p. Illus. 81 ref. |
| Abstract |
Conclusions of this criteria document on vinylidene fluoride (VDF): VDF has low acute and chronic toxicity in laboratory animals. It is not genotoxic either in vitro or in vivo. Although rats developed carcinomas in a one-year oral study, subsequent lifetime inhalation studies in rats and mice showed no adverse effects at high doses. It is therefore unlikely that VDF has significant long-term toxic or carcinogenic properties. VDF has no effects on rat fertility or reproduction. A teratology study did not indicate any embryotoxic, foetotoxic or teratogenic effects at high concentrations. There are no data on the effects of human exposure. The ACGIH has established a threshold limit value of 500ppm or 1300mg/m3. |
| Descriptors (primary) |
1,1-difluoroethylene; toxicology |
| Descriptors (secondary) |
threshold limit values; acute toxicity; criteria document; chronic toxicity; animal experiments |
| Document type |
B - Chemical safety information sheets |
| Country / State or Province | Belgium |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
Chemical safety
|
| Browse category(ies) |
Halogenated hydrocarbons
Fluorocarbons
|
