|Document ID (ISN)||105844|
|ISSN - Serial title
||1351-0711 - Occupational and Environmental Medicine
|Convention or series no.
||Chia S.E., Zhou H.J., Yap E., Tham M.T., Dong N.V., Hong Tu N.T., Chia K.S.
||Association of renal function and δ-aminolevulinic acid dehydratase polymorphism among Vietnamese and Singapore workers exposed to inorganic lead
||2006, Vol. 63, p.180-186. Illus. 23 ref.
||The effect of δ-aminolevulinic acid dehydratase (ALAD) polymorphisms on the association between blood lead and renal function was investigated among Vietnamese and Singaporean workers exposed to low to medium levels of inorganic lead. The distribution of ALAD polymorphism among Vietnamese, Chinese, Malays and Indians was also studied. Blood and urine samples were analysed for blood lead, ALAD genotype, urinary δ-aminolevulinic acid and renal function. ALAD1-1 was the predominant genotype for all ethnic groups while ALAD2-2 was the rarest. Results indicated that workers with the ALAD2 allele appeared to be more susceptible to the effects of lead (especially at higher levels) on renal function.
||lead; individual susceptibility; renal function tests; renal diseases
||Singapore; determination in urine; determination in blood; Viet Nam
||D - Periodical articles
|Country / State or Province||Singapore; Viet Nam|
Toxic and dangerous substances
|Broad subject area(s)
Occupational medicine, epidemiology
||Diseases of the kidney and the urinary system
Lead and compounds