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Document ID (ISN)105843
CIS number 06-1340
ISSN - Serial title 0091-6765 - Environmental Health Perspectives
Year 2005
Convention or series no.
Author(s) Chia S.E., Zhou H., Tham M.T., Yap E., Dong N.V., Hong Tu N.T., Chia K.S.
Title Possible influence of δ-aminolevulinic acid dehydratase polymorphism and susceptibility to renal toxicity of lead: A study of a Vietnamese population
Bibliographic information Oct. 2005, Vol.113, No.10, p.1313-1317. Illus. 33 ref.
Abstract In a cross-sectional study of 276 lead-exposed workers in Vietnam, all workers were measured for blood lead levels and for various urinary markers of renal toxicity. Six newly identified polymorphisms located on the ALAD (δ-aminolevulinic acid dehydratase) gene were examined to determine whether they could modify the relationship between blood lead and some renal parameters. It was found that one polymorphism was able to modify the association of blood lead concentrations with certain renal parameters. Further studies are needed to confirm this observation.
Descriptors (primary) lead; individual susceptibility; renal function tests; renal diseases
Descriptors (secondary) Viet Nam; determination in urine; determination in blood
Document type D - Periodical articles
Country / State or ProvinceSingapore; Viet Nam
Subject(s) Occupational pathology
Toxic and dangerous substances
Broad subject area(s) Chemical safety
Occupational medicine, epidemiology
Browse category(ies) Diseases of the kidney and the urinary system
Lead and compounds
Inorganic substances