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Document ID (ISN)105396
CIS number 06-899
ISSN - Serial title 0271-3586 - American Journal of Industrial Medicine
Year 2005
Convention or series no.
Author(s) Karakaya A.E., Ozcagli E., Ertas N., Sardas S.
Title Assessment of abnormal DNA repair responses and genotoxic effects in lead exposed workers
Bibliographic information Apr. 2005, Vol.47, No.4, p.358-363. Illus. 23 ref.
Abstract Genotoxic effects of lead were studied in blood cell samples from 23 workers of battery manufacturing plants and 23 unexposed controls. Tests included chromosomal aberration (CA) assay and X-ray induced challenge (XRC) assay to assess DNA damage and interference with DNA repair processes after an in vitro exposure of X-ray. Cases were classified into categories according to their blood lead levels. The CA frequencies in the exposed and control groups were not significantly different by the conventional CA assay, however, the XRC assay demonstrated significantly elevated CAs. Non-significant but reduced DNA repair responses were also observed in lead exposed workers. The results suggest that lead exposure may cause reduction in DNA repair capacity.
Descriptors (primary) lead and compounds; DNA; battery and dry cell manufacture; chromosome changes; genetic effects
Descriptors (secondary) Turkey; lead; x-rays; determination in blood; analysis of chromosome aberrations; case-control study
Document type D - Periodical articles
Country / State or ProvinceTurkey
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Inorganic substances
Lead and compounds
Genetic factors in reaction to exposures
Antifertility and prenatal effects
Manufacturing of electrical appliances and equipment