|Document ID (ISN)||105392|
|ISSN - Serial title
||0271-3586 - American Journal of Industrial Medicine
|Convention or series no.
||London L., Flisher A.J., Wesseling C., Mergler D., Kromhout H.
||Suicide and exposure to organophosphate insecticides: Cause or effect?
||Apr. 2005, Vol.47, No.4, p.308-321. Illus. 132 ref.
||A literature review was performed of mortality and morbidity studies related to suicide among pesticide-exposed populations, and of human and animal studies of central nervous system toxicity related to organophosphate (OP) pesticides. Suicide rates are high in farming populations. Animal studies link OP exposure to serotonin disturbances in the central nervous system, a mechanism that is implicated in depression and suicide in humans. Various epidemiological studies conclude that acute and chronic OP exposure is associated with affective disorders. Other studies also support a causal association between OP use and suicide. It is concluded that OPs are not only agents for suicide, but may be part of the causal pathway.
||neurotoxic effects; pesticide poisoning; agriculture; pesticides; suicide; organophosphorus compounds
||literature survey; animal experiments; depressive neurosis; case study
||D - Periodical articles
|Country / State or Province||Canada; Costa Rica; Netherlands; South Africa|
||Agriculture, fishing, animal husbandry
|Broad subject area(s)
||Stress, psychosocial factors
Diseases of the nervous system