| Document ID (ISN) | 105051 |
| CIS number |
06-627 |
| ISSN - Serial title |
0340-0131 - International Archives of Occupational and Environmental Health |
| Year |
2005 |
| Convention or series no. |
|
| Author(s) |
Haufroid V., Lison D. |
| Title |
Mercapturic acids revisited as biomarkers of exposure to reactive chemicals in occupational toxicology: A minireview |
| Bibliographic information |
June 2005, Vol.78, No.5, p.343-354. Illus. 75 ref. |
| Internet access |
http://www.springerlink.com/media/3pvxje0mrh1wqp9d9dcg/contributions/v/7/u/2/v7u2t32222p28q74.pdf [in English]
|
| Abstract |
This short literature review examines the use of mercapturic acids as a biological exposure index for electrophilic chemicals. The review considers the analytical methods available to measure mercapturic acids, the advantages of mercapturic acids compared to other well-validated biomarkers and the high inter-individual variability in mercapturic acids excretion. Recent field and experimental studies confirm the usefulness of mercapturic acids as a biological exposure index for electrophilic chemicals and highlight the advantages of a toxicogenetic approach for a better interpretation of the results of biological monitoring. |
| Descriptors (primary) |
mercapturic acid; exposure tests; chemical products; toxic substances |
| Descriptors (secondary) |
literature survey; DNA; determination in urine; urinary metabolites; chromosome changes; exposure evaluation |
| Document type |
D - Periodical articles |
| Country / State or Province | Belgium |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
Chemical safety
|
| Browse category(ies) |
Biological monitoring
Genetic factors in reaction to exposures
Toxicology
|
