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CISDOC database

Document ID (ISN)105013
CIS number 06-615
ISSN - Serial title 0340-0131 - International Archives of Occupational and Environmental Health
Year 2005
Convention or series no.
Author(s) Voss J.U., Roller M., Brinkmann E., Mangelsdorf I.
Title Nephrotoxicity of organic solvents: Biomarkers for early detection
Bibliographic information July 2005, Vol.78, No.6, p.475-485. Illus. 74 ref.
Abstract An analysis of the available literature was performed with respect to markers measured in cross-sectional studies that might be useful for the early detection of solvent-induced effects on the kidney. Various markers were analysed with respect to their suitability as biomarkers for renal damage. An increased albumin excretion was observed more frequently in groups of workers exposed to solvents such as toluene, styrene, mixtures of aliphatic and aromatic hydrocarbons, tetrachloroethylene, and mixtures of chlorinated hydrocarbons than in controls. No clear pattern emerged for the other markers. It is concluded that the determination of albumin excretion in the urine appears to be a useful parameter for monitoring solvent-exposed workers.
Descriptors (primary) renal diseases; exposure tests; nephrotoxic effects; organic solvents
Descriptors (secondary) literature survey; tetrachloroethylene; toluene; styrene; determination in urine; case-control study; cross-sectional study; chlorinated hydrocarbons; proteinuria
Document type D - Periodical articles
Country / State or ProvinceGermany
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Biological monitoring
Diseases of the kidney and the urinary system