| Document ID (ISN) | 105013 |
| CIS number |
06-615 |
| ISSN - Serial title |
0340-0131 - International Archives of Occupational and Environmental Health |
| Year |
2005 |
| Convention or series no. |
|
| Author(s) |
Voss J.U., Roller M., Brinkmann E., Mangelsdorf I. |
| Title |
Nephrotoxicity of organic solvents: Biomarkers for early detection |
| Bibliographic information |
July 2005, Vol.78, No.6, p.475-485. Illus. 74 ref. |
| Abstract |
An analysis of the available literature was performed with respect to markers measured in cross-sectional studies that might be useful for the early detection of solvent-induced effects on the kidney. Various markers were analysed with respect to their suitability as biomarkers for renal damage. An increased albumin excretion was observed more frequently in groups of workers exposed to solvents such as toluene, styrene, mixtures of aliphatic and aromatic hydrocarbons, tetrachloroethylene, and mixtures of chlorinated hydrocarbons than in controls. No clear pattern emerged for the other markers. It is concluded that the determination of albumin excretion in the urine appears to be a useful parameter for monitoring solvent-exposed workers. |
| Descriptors (primary) |
renal diseases; exposure tests; nephrotoxic effects; organic solvents |
| Descriptors (secondary) |
literature survey; tetrachloroethylene; toluene; styrene; determination in urine; case-control study; cross-sectional study; chlorinated hydrocarbons; proteinuria |
| Document type |
D - Periodical articles |
| Country / State or Province | Germany |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
Chemical safety
|
| Browse category(ies) |
Biological monitoring
Diseases of the kidney and the urinary system
|
