Document ID (ISN) | 105012 |
CIS number |
06-614 |
ISSN - Serial title |
0340-0131 - International Archives of Occupational and Environmental Health |
Year |
2005 |
Convention or series no. |
|
Author(s) |
Sakai T., Morita Y., Roh J., Kim H., Kim Y. |
Title |
Improvement in the GC-MS method for determining urinary toluene-diamine and its application to the biological monitoring of workers exposed to toluene-diisocyanate |
Bibliographic information |
July 2005, Vol.78, No.6, p.459-466. Illus. 22 ref. |
Abstract |
The objective of this study was to develop a simple and sensitive gas chromatography-mass spectrometry (GC-MS) method for determining toluene-diamine (TDA) in urine and to apply the method for biological monitoring of workers exposed to toluene-diisocyanate (TDI). The method involved acid hydrolysis urine followed by the extraction of the free TDA with dichloromethane and the determination of the heptafluorobutyric anhydride derivative by GC-MS. This method was applied to the biological monitoring of 18 workers exposed to an 80:20 mixture of 2,4-TDI and 2,6-TDI. The method was found to be simple and practicable, showing a good correlation with personal TDI exposures. |
Descriptors (primary) |
tolylene diisocyanate; determination in urine; exposure tests |
Descriptors (secondary) |
mass spectrometry; 2,6-tolylene diisocyanate; gas chromatography; exposure evaluation; description of technique; 2,4-tolylene diisocyanate |
Document type |
D - Periodical articles |
Country / State or Province | Japan; Korea, Republic of |
Subject(s) |
Toxic and dangerous substances
|
Broad subject area(s) |
Chemical safety
|
Browse category(ies) |
Biological monitoring Isocyanates Cyano compounds
|