|Document ID (ISN)||104997|
|ISSN - Serial title
||0271-3586 - American Journal of Industrial Medicine
|Convention or series no.
||One agent, many diseases: Exposure-response data and comparative risks of different outcomes following silica exposure
||July 2005, Vol.48, No.1, p.16-23. Illus. 40 ref.
||Evidence in recent years indicates that silica causes lung cancer and renal disease in addition to its well-known relationship to silicosis. The available exposure-response data for silica and silicosis, lung cancer and renal disease were reviewed. The risks of death or disease incidence by age 75 were compared for these three diseases, subsequent to 45 years of exposure to silica at the current exposure limit of 0.1mg/m3 respirable crystalline silica. The absolute risk of silicosis ranged from 47% to 77%. The absolute risk of death from silicosis was estimated at 1.9%. The excess risk of lung cancer death, assuming US male background rates, was 1.7%. The excess risk of end-stage renal disease was 5.1%, and the excess risk of death from renal disease was estimated to be 1.8%. Given that the usual OSHA acceptable excess risk of serious disease or death for workers is 0.1%, it is clear that the current limit is far from sufficiently protective of workers' health. Kidney disease emerges as a higher risk than either mortality from silicosis or lung cancer, although the data are based on fewer studies.
||silica; silicosis; lung cancer; renal diseases
||literature survey; threshold limit values; USA; frequency rates; mortality; dose-response relationship; morbidity
||D - Periodical articles
|Country / State or Province||USA|
Toxic and dangerous substances
|Broad subject area(s)
Occupational medicine, epidemiology
||Diseases of the kidney and the urinary system
Diseases of the respiratory system (except for pneumoconiosis & similar)