| Document ID (ISN) | 104674 |
| CIS number |
06-141 |
| ISSN - Serial title |
1077-3525 - International Journal of Occupational and Environmental Health |
| Year |
2004 |
| Convention or series no. |
|
| Author(s) |
Liu Y., Berode M., Stowe M.H., Holm C.T., Walsh F.X., Slade M.D., Boeniger M.F., Redlich C.A. |
| Title |
Urinary hexane diamine to assess respiratory exposure to hexamethylene diisocyanate aerosol: A human inhalation study |
| Bibliographic information |
July-Sep. 2004, Vol.10, No.3, p.262-271. Illus. 34 ref. |
| Internet access |
http://www.ijoeh.com/pfds/1003_Liu.pdf [in English]
|
| Abstract |
The use of urinary hexane diamine (HDA) as a biomarker to assess respiratory exposure to hexamethylene diisocyanate (HDI) aerosol was evaluated. Twenty-three auto body shop workers were exposed for two hours to HDI biuret aerosol. HDI exposures were quantified. Urine samples were collected at baseline, immediately post exposure, and every 4-5 hours up to 20 hours and analyzed for HDA using gas chromatography and mass spectrometry. Mean urinary HDA (mgg/g creatinine) increased sharply from the baseline value of 0.7 to 18.1 post exposure and decreased rapidly to 4.7, 1.9 and 1.1, respectively, at 4, 9 and 18 hours post exposure. Considerable individual variability was found. Urinary HDA can assess acute respiratory exposure to HDI aerosol but may however have limited use as a biomarker of exposure in the workplace. |
| Descriptors (primary) |
hexamethylene diisocyanate; exposure tests; aerosols |
| Descriptors (secondary) |
mass spectrometry; hexamethylene diisocyanate biuret; exposure evaluation; determination in urine; description of technique; gas chromatography; determination in air |
| Document type |
D - Periodical articles |
| Country / State or Province | Switzerland; USA |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
Chemical safety
|
| Browse category(ies) |
Cyano compounds
Biological monitoring
Isocyanates
|
