| Document ID (ISN) | 104666 |
| CIS number |
06-204 |
| ISSN - Serial title |
1076-2752 - Journal of Occupational and Environmental Medicine |
| Year |
2003 |
| Convention or series no. |
|
| Author(s) |
Nordness M.E., Zacharisen M.C., Schlueter D.P., Fink J.N. |
| Title |
Occupational lung disease related to Cytophaga endotoxin exposure in a nylon plant |
| Bibliographic information |
Apr. 2003, Vol.45, No.4, p.385-392. Illus. 31 ref. |
| Abstract |
Workers at a nylon plant developed pulmonary disease with systemic symptoms. Cytophaga, an endotoxin-producing bacteria, was isolated from the plant air-conditioning system. Several workers underwent lung biopsies, demonstrating hypersensitivity pneumonitis (HP). Inhalation challenges with purified Cytophaga endotoxin were performed on three groups of subjects: employees with clinical features and biopsy consistent with HP (group 1); asymptomatic exposed workers with precipitins (group 2); and non-exposed healthy individuals (group 3). All subjects had fever and leukocytosis after inhalation challenge. Acute and/or late pulmonary function changes occurred in groups 1 and 2. Group 3 only had acute and transient pulmonary function changes. It is concluded that the Cytophaga bacterial endotoxin is capable of inducing HP as well as humidifier fever. |
| Descriptors (primary) |
synthetic fibre industry; air conditioner disease; bacterial toxins; extrinsic allergic alveolitis |
| Descriptors (secondary) |
respiratory diseases; air conditioning; serum precipitins; allergy tests; pulmonary function |
| Document type |
D - Periodical articles |
| Country / State or Province | USA |
| Subject(s) |
Occupational pathology
|
| Broad subject area(s) |
Biological hazards
Occupational medicine, epidemiology
|
| Browse category(ies) |
Pneumoconioses
|
