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Document ID (ISN)104651
CIS number 06-132
ISSN - Serial title 1231-868X - Podstawy i Metody Oceny Środowiska Pracy
Year 2005
Convention or series no.
Author(s) Sitarek K.
Title N-Methyl-2-pyrrolidone: Documentation of maximum admissible values for occupational exposure
Original title 1-Metylo-2-pirolidon: Dokumentacja proponowanych wartości dopuszczalnych wielkości narażenia zawodowego [in Polish]
Bibliographic information 2005, Vol.43, No.1, p.103-115. 26 ref.
Abstract N-methyl-2-pyrrolidone (methylpyrrolidinone, NMP) is an industrial solvent. It can be absorbed through the skin. The substance is not mutagenic, genotoxic or carcinogenic but it is embryotoxic, foetotoxic and teratogenic at doses which are non-toxic to the mothers. On the basis that it disturbs prenatal development in more than one animal species, in the Scandinavian countries NMP has been classified in the IB group, which comprises substances probably harmful to human reproduction. Based on the NOAEL value obtained in an experimental study (500 mg/m3) and appropriate uncertainty factors, a TLV of 120 mg/m3 and a short-term exposure level of 240 mg/m3 have been proposed. In addition, notations are suggested for irritation, foetotoxicity and skin absorption.
Descriptors (primary) toxic effects; threshold limit values; methylpyrrolidinone; solvents; toxicology
Descriptors (secondary) embryotoxic effects; irritants; teratogenic effects; skin absorption; Poland
Document type D - Periodical articles
Country / State or ProvincePoland
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Occupational exposure limits
Heterocyclic compounds
Genetic factors in reaction to exposures