| Document ID (ISN) | 104649 |
| CIS number |
06-130 |
| ISSN - Serial title |
1231-868X - Podstawy i Metody Oceny Środowiska Pracy |
| Year |
2005 |
| Convention or series no. |
|
| Author(s) |
Gralewicz S. |
| Title |
Dinitrophenol - mixture of isomers: Documentation of maximum admissible values for occupational exposure |
| Original title |
Dinitrofenol - mieszanina izomerów: Dokumentacja proponowanych wartości dopuszczalnych wielkości narażenia zawodowego [in Polish] |
| Bibliographic information |
2005, Vol.43, No.1, p.67-89. 86 ref. |
| Abstract |
Dinitrophenol (DNP) is a mixture of 2,4-DNP and smaller amounts of 2,3-DNP and 2,6-DNP. It is a yellow, crystalline solid. Short-term exposure to DNP may affect metabolism resulting in hyperthermia. High-level exposure may be fatal. The existing data concerning the health effects of 2,4-DNP oral exposure in humans indicate that the characteristic effects of 2,4-DNP for this route are: increased basal metabolic rate and perspiration, weight loss, a sensation of warmth and, at higher dosage, increased heart and respiratory rate, and increased body temperature. Taking into account the results obtained in clinical studies on people ingesting 2,4-DNP (LOAEL for metabolic effects was 1.2 mg/kg/day), a concentration of 0.5 mg of dinitrophenol/m3 is proposed as a maximum exposure limit (maximum admissible concentration) with a skin notation. |
| Descriptors (primary) |
toxic effects; dinitrophenol; toxicology; threshold limit values |
| Descriptors (secondary) |
irritants; Poland; skin absorption; respiratory rate; metabolic disturbances; skin allergies; pulse rate; body temperature |
| Document type |
D - Periodical articles |
| Country / State or Province | Poland |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
Chemical safety
|
| Browse category(ies) |
Occupational exposure limits
|
