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Document ID (ISN)104267
CIS number 05-519
ISSN - Serial title 1231-868X - Podstawy i Metody Oceny Środowiska Pracy
Year 2002
Convention or series no.
Author(s) Starek A.
Title N,N-Dimethylaniline
Original title N,N-Dimetyloanilina [in Polish]
Bibliographic information 2002, Vol.33, No.3, p.103-116. 30 ref.
Abstract N,N-Dimethylaniline (DMA) is used as a solvent and chemical intermediate for organic synthesis. Exposure to this compound in industry is poorly documented. Experimental exposure to DMA in both humans and laboratory animals resulted in the following haematotoxic effects: symptoms of cyanosis; spleen enlargement; methaemoglobinaemia; extra marrow haematopoesis. DMA is clastogenic. However, carcinogenic, embryotoxic and teratogenic effects have not been confirmed. Based on the haematotoxic effects observed on rats administered DMA intragastrically, a LOAEL value of 31.25mg/m3 was determined, from which a threshold limit value (time-weighted average) of 12mg/m3 was derived, and a short-term exposure limit value of 40mg/m3 was proposed. Furthermore, a methaemoglobin concentration of 2% in peripheral blood was proposed as a biological exposure index value.
Descriptors (primary) Poland; health hazards; toxicology; N,N-dimethylaniline
Descriptors (secondary) literature survey; threshold limit values; chemical industry; splenic diseases; skin absorption; hypoxia; methaemoglobinaemia; permissible levels; animal experiments; determination of exposure limits; haematotoxic effects; biological threshold limits; criteria document; solvents
Document type B - Chemical safety information sheets
Country / State or ProvincePoland
Subject(s) Toxic and dangerous substances
Broad subject area(s)
Browse category(ies) Aromatic amines