| Document ID (ISN) | 104257 |
| CIS number |
05-509 |
| ISSN - Serial title |
1231-868X - Podstawy i Metody Oceny Środowiska Pracy |
| Year |
2002 |
| Convention or series no. |
|
| Author(s) |
Sapota A., Kilanowicz A. |
| Title |
5-Methyl-2-hexanone |
| Original title |
5-Metyloheksan-2-on [in Polish] |
| Bibliographic information |
2002, Vol.31, No.1, p.99-109. 20 ref. |
| Abstract |
Occupational exposure to 5-methyl-2-hexanone (methyl isoamyl ketone) occurs through inhalation and dermal contact during production and use of this compound. There are no available data concerning toxic effects in humans. In laboratory animals, it shows a weak irritating action on the skin and eyes and irritating activity on the respiratory tract, the RD50 value for mice being 5695mg/m3. In a long-term experiment on rats, no harmful effects were observed at a concentration of 923mg/m3, which is taken as the no observed adverse effect level. There are indications of nephrotoxic and hepatotoxic effects. The calculated threshold limit value (time-weighted average) of 116.5mg/m3 is only slightly greater than the corresponding value accepted in the European Union (95mg/m3). Thus, it is suggested that this latter value be accepted. |
| Descriptors (primary) |
Poland; health hazards; toxicology; 5-methyl-2-hexanone |
| Descriptors (secondary) |
threshold limit values; irritants; hepatotoxic effects; skin absorption; criteria document; animal experiments; determination of exposure limits; nephrotoxic effects; permissible levels |
| Document type |
B - Chemical safety information sheets |
| Country / State or Province | Poland |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
|
| Browse category(ies) |
Ketones
|
