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Document ID (ISN)104251
CIS number 05-503
ISSN - Serial title 1231-868X - Podstawy i Metody Oceny Środowiska Pracy
Year 2002
Convention or series no.
Author(s) Starek A.
Title 4-Aminobiphenyl
Original title Bifenylo-4-amina [in Polish]
Bibliographic information 2002, Vol.31, No.1, p.5-23. Illus. 78 ref.
Abstract 4-Aminobiphenyl is used in the rubber industry as an antioxidant and in the synthesis of azo dyes. It has a relatively low toxicity but is highly genotoxic and carcinogenic. The oral LD50 values for this compound in rodents range from 205 to 500mg/kg. 4-Aminobiphenyl and its metabolite N-hydroxy-4-aminobiphenyl demonstrate the ability to induce gene mutations in bacterial tests. This and other metabolites produce adducts with the DNA and RNA of bladder epithelial cells. The carcinogenic potential of 4-aminobiphenyl has been evidenced in some animal species and in humans. The substance induces bladder tumours. A threshold limit value (time-weighted average) of 0.001mg/m3 is proposed.
Descriptors (primary) Poland; health hazards; toxicology; 4-aminobiphenyl
Descriptors (secondary) mutagenic effects; threshold limit values; carcinogens; rubber industry; bladder tumour; animal experiments; antioxidants; determination of exposure limits; chromosome changes; cytotoxic effects; dyestuff industry; criteria document; in vitro experiments
Document type B - Chemical safety information sheets
Country / State or ProvincePoland
Subject(s) Toxic and dangerous substances
Broad subject area(s)
Browse category(ies) Aromatic amines
Genetic factors in reaction to exposures