Document ID (ISN) | 104251 |
CIS number |
05-503 |
ISSN - Serial title |
1231-868X - Podstawy i Metody Oceny Środowiska Pracy |
Year |
2002 |
Convention or series no. |
|
Author(s) |
Starek A. |
Title |
4-Aminobiphenyl |
Original title |
Bifenylo-4-amina [in Polish] |
Bibliographic information |
2002, Vol.31, No.1, p.5-23. Illus. 78 ref. |
Abstract |
4-Aminobiphenyl is used in the rubber industry as an antioxidant and in the synthesis of azo dyes. It has a relatively low toxicity but is highly genotoxic and carcinogenic. The oral LD50 values for this compound in rodents range from 205 to 500mg/kg. 4-Aminobiphenyl and its metabolite N-hydroxy-4-aminobiphenyl demonstrate the ability to induce gene mutations in bacterial tests. This and other metabolites produce adducts with the DNA and RNA of bladder epithelial cells. The carcinogenic potential of 4-aminobiphenyl has been evidenced in some animal species and in humans. The substance induces bladder tumours. A threshold limit value (time-weighted average) of 0.001mg/m3 is proposed. |
Descriptors (primary) |
Poland; health hazards; toxicology; 4-aminobiphenyl |
Descriptors (secondary) |
mutagenic effects; threshold limit values; carcinogens; rubber industry; bladder tumour; animal experiments; antioxidants; determination of exposure limits; chromosome changes; cytotoxic effects; dyestuff industry; criteria document; in vitro experiments |
Document type |
B - Chemical safety information sheets |
Country / State or Province | Poland |
Subject(s) |
Toxic and dangerous substances
|
Broad subject area(s) |
|
Browse category(ies) |
Genetic factors in reaction to exposures Aromatic amines
|