|Document ID (ISN)||104251|
|ISSN - Serial title
||1231-868X - Podstawy i Metody Oceny Środowiska Pracy
|Convention or series no.
||Bifenylo-4-amina [in Polish]|
||2002, Vol.31, No.1, p.5-23. Illus. 78 ref.
||4-Aminobiphenyl is used in the rubber industry as an antioxidant and in the synthesis of azo dyes. It has a relatively low toxicity but is highly genotoxic and carcinogenic. The oral LD50 values for this compound in rodents range from 205 to 500mg/kg. 4-Aminobiphenyl and its metabolite N-hydroxy-4-aminobiphenyl demonstrate the ability to induce gene mutations in bacterial tests. This and other metabolites produce adducts with the DNA and RNA of bladder epithelial cells. The carcinogenic potential of 4-aminobiphenyl has been evidenced in some animal species and in humans. The substance induces bladder tumours. A threshold limit value (time-weighted average) of 0.001mg/m3 is proposed.
||Poland; health hazards; toxicology; 4-aminobiphenyl
||mutagenic effects; threshold limit values; carcinogens; rubber industry; bladder tumour; animal experiments; antioxidants; determination of exposure limits; chromosome changes; cytotoxic effects; dyestuff industry; criteria document; in vitro experiments
||B - Chemical safety information sheets
|Country / State or Province||Poland|
||Toxic and dangerous substances
|Broad subject area(s)
Genetic factors in reaction to exposures