| Document ID (ISN) | 104251 |
| CIS number |
05-503 |
| ISSN - Serial title |
1231-868X - Podstawy i Metody Oceny Środowiska Pracy |
| Year |
2002 |
| Convention or series no. |
|
| Author(s) |
Starek A. |
| Title |
4-Aminobiphenyl |
| Original title |
Bifenylo-4-amina [in Polish] |
| Bibliographic information |
2002, Vol.31, No.1, p.5-23. Illus. 78 ref. |
| Abstract |
4-Aminobiphenyl is used in the rubber industry as an antioxidant and in the synthesis of azo dyes. It has a relatively low toxicity but is highly genotoxic and carcinogenic. The oral LD50 values for this compound in rodents range from 205 to 500mg/kg. 4-Aminobiphenyl and its metabolite N-hydroxy-4-aminobiphenyl demonstrate the ability to induce gene mutations in bacterial tests. This and other metabolites produce adducts with the DNA and RNA of bladder epithelial cells. The carcinogenic potential of 4-aminobiphenyl has been evidenced in some animal species and in humans. The substance induces bladder tumours. A threshold limit value (time-weighted average) of 0.001mg/m3 is proposed. |
| Descriptors (primary) |
Poland; health hazards; toxicology; 4-aminobiphenyl |
| Descriptors (secondary) |
mutagenic effects; threshold limit values; carcinogens; rubber industry; bladder tumour; animal experiments; antioxidants; determination of exposure limits; chromosome changes; cytotoxic effects; dyestuff industry; criteria document; in vitro experiments |
| Document type |
B - Chemical safety information sheets |
| Country / State or Province | Poland |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
|
| Browse category(ies) |
Genetic factors in reaction to exposures
Aromatic amines
|
