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CISDOC database

Document ID (ISN)104222
CIS number 05-374
ISSN - Serial title 1080-3548 - International Journal of Occupational Safety and Ergonomics
Year 2004
Convention or series no.
Author(s) Zapˇr L.
Title Toxicity of some phenolic derivatives - In vitro studies
Bibliographic information 2004, Vol.10, No.4, p.319-331. Illus. 38 ref.
Abstract The cytotoxicity of five phenolic compounds (phenol, catechol, resorcinol, hydroquinone and phloroglucinol) was tested using a mouse 3T3 fibroblast cell line. Linear regression analysis and Pearson's correlation coefficient were used to characterize the relationship between cytotoxicity expressed as IC50 and physicochemical parameters of compounds or their toxicity in vivo expressed as LD50. The studies showed that the physicochemical properties of the compounds seemed to have less influence on their cytotoxic potency than did their structural properties. The cytotoxicity of the compounds probably depends on the number of hydroxyl groups and their location in the aromatic ring more than on physicochemical properties of compounds. The best correlation was obtained for IC50 values and LD50 values determined following rabbit skin administration and experimental skin irritation score.
Descriptors (primary) phenol; resorcinol; pyrocatechol; hydroquinone; in vitro experiments; cytotoxic effects; toxicity evaluation
Descriptors (secondary) irritants; molecular structure; description of technique; skin tests; cell culture
Document type D - Periodical articles
Country / State or ProvincePoland
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Phenols and phenolic compounds
Alcohols