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Document ID (ISN)104019
CIS number 05-380
ISSN - Serial title 0271-3586 - American Journal of Industrial Medicine
Year 2004
Convention or series no.
Author(s) Rosenman K.D., Reilly M.J.
Title Cancer mortality and incidence among a cohort of benzidine and dichlorobenzidine dye manufacturing workers
Bibliographic information Nov. 2004, Vol.46, No.5, p.505-512. 32 ref.
Abstract 538 workers potentially exposed to benzidine and/or dichlorobenzidine at a chemical manufacturing facility were followed. Vital status through 2001 and cancer incidence through 2002 were determined for all employees who worked at the facility from 1960 to 1977. 22 bladder cancer cases were identified. For three individuals, bladder cancer was the underlying cause of death. Increased standardized mortality ratios (SMRs) were 1.54 for all cancers, 8.34 for bladder cancer and 2.84 for lymphohaematopoietic cancer. The standardized incidence ratio (SIR) for bladder cancer was 6.85. Among the workers who were exposed to dichlorobenzidine only, there was a single case of bladder cancer, but an increased risk for lymphohaematopoietic cancer (SMR 6.62). This study confirms the high risk of bladder cancer among benzidine exposed workers even years after exposure has ceased, and raises suggestive evidence of increased risk of lymphohaematopoietic cancer from exposure to benzidine or dichlorobenzidine.
Descriptors (primary) dichlorobenzidine; morbidity; benzidine; cancer; risk factors; mortality
Descriptors (secondary) lymphatic leukaemia; bladder tumour; hazard evaluation; frequency rates; long-term exposure; length of exposure; cohort study
Document type D - Periodical articles
Country / State or ProvinceUSA
Subject(s) Chemicals, plastics and rubber
Broad subject area(s) Chemical safety
Occupational medicine, epidemiology
Browse category(ies) Aromatic amines