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Document ID (ISN)103976
CIS number 05-7
ISSN - Serial title 1877-7856 - Encyclopédie médico-chirurgicale
Year 2004
Convention or series no. Fascicule 16046 S 30, 4-2004
Author(s) Villa A.F., Conso F.
Title Aromatic amines
Original title Amines aromatiques [in French]
Bibliographic information Toxicologie-Pathologie professionnelle, 4th Quarter 2004, No.145, 11p. Illus. 91 ref.
Abstract While aromatic amines form part of one family of chemical compounds, their toxicity varies from one substance to another. They are used in a wide variety of industries. Contamination can occur through the skin, by inhalation or by ingestion. Acute toxic effects include methaemoglobinaemia (aniline), haemolytic anaemia and hepatitis (MDA), rhabdomyolysis with renal insufficiency, cardiomyopathy or eye disorders. Chronic effects can include irritation, and skin or respiratory sensitization (paraphenylene diamine). Several of these componds (benzidine, 2-naphtylamine) are known human carcinogens. Occupational bladder cancer is the most frequent cancer caused by exposure to aromatic amines. Regulations include a ban on the use of carcinogenic amines in occupational settings and the surveillance of previously-exposed workers.
Descriptors (primary) carcinogens; France; toxic substances; toxicology; aromatic amines
Descriptors (secondary) irritants; prohibition of use; visual function disorders; renal dysfunction; aniline; 2-naphthylamine; haemolytic anaemia; bladder tumour; muscular diseases; sensitizers; toxic hepatitis; cardiotoxic effects; medical supervision; benzidine; encyclopaedia; data sheet; methaemoglobinaemia; methylenedianiline
Document type B - Chemical safety information sheets
Country / State or ProvinceFrance
Subject(s) Toxic and dangerous substances
Broad subject area(s)
Browse category(ies) Aromatic amines