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Document ID (ISN)103920
CIS number 05-165
ISSN - Serial title 0271-3586 - American Journal of Industrial Medicine
Year 2003
Convention or series no.
Author(s) Cassidy L.D., Youk A.O., Marsh G.M.
Title The Drake Health Registry Study: Cause-specific mortality experience of workers potentially exposed to beta-naphthylamine
Bibliographic information Sep. 2003, Vol.44, No.3, p.282-290. 36 ref.
Abstract The objective of this study was to examine the cause-specific mortality experience of a cohort with past exposure to beta-naphthylamine (BNA). Subjects were 374 male and 26 female workers employed at a chemical plant that produced or used BNA between 1940 and 1981. Vital status through 1998 was determined for 97.5% of the cohort and cause of death for 100% of 79 deaths. Industrial hygiene data and reports from former employees were used to categorize workers as high, medium, or low risk for BNA exposure. Standardized mortality ratios (SMRs) were calculated on the basis of mortality data of the local population. Statistically-significantly elevated SMRs were observed for all causes (SMR=1.98), all malignant neoplasms (28 deaths, SMR=3.08), respiratory system cancer (12 deaths, SMR=3.91) and bladder cancer (four deaths, SMR=16.83). Mortality risks were also elevated for most other malignant and non-malignant diseases examined.
Descriptors (primary) chemical industry; occupational diseases; risk factors; mortality; cancer; 2-naphthylamine
Descriptors (secondary) bladder tumour; respiratory diseases; chemical plant; neoplasms; long-term study; long-term exposure; frequency rates; cohort study
Document type D - Periodical articles
Country / State or ProvinceUSA
Subject(s) Occupational pathology
Toxic and dangerous substances
Broad subject area(s) Chemical safety
Occupational medicine, epidemiology
Browse category(ies) Aromatic amines
Chemical industry