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Document ID (ISN)103825
CIS number 05-156
ISSN - Serial title 1250-3274 - Archives des maladies professionnelles et de mÚdecine du travail
Year 2003
Convention or series no.
Author(s) Garnier R., Bazire A., Chataigner D.
Title Health effects of the occupational use of paraquat
Original title Effet sur la santÚ de l'utilisation professionnelle du paraquat [in French]
Bibliographic information Sep. 2003, Vol.64, No.5, p.310-324. 119 ref.
Abstract In exposed workers, paraquat is mostly responsible for local irritant effects on the skin, nails and mucous membranes. Skin lesions result from direct and prolonged contact with paraquat solutions, especially during the dilution of concentrates or after the wetting of protective clothing during spraying. Paronychia and nail damage may result from contamination of the extremities. Skin damage consists in burns, blisters or ulceration at the site of contact. There are several reports of cases of severe burns of the back, buttocks and groin after dermal exposure from a leaking knapsack sprayer. Eye splashes can result in severe blepharitis, keratitis, and conjunctivitis. Inhalation exposure is often responsible for epistasis and epigastralgia. These local effects are prevented by good application practices and the use of protective equipment. The use of knapsack sprayers is potentially responsible for severe accidents and should be abandoned. Systemic paraquat poisoning has been reported after percutaneous exposure and has resulted in around 20 deaths. The features of paraquat poisoning following dermal absorption are moderate hepatic damage, reversible renal tubular necrosis, and most importantly, pulmonary fibrosis, which is the cause of death.
Descriptors (primary) pesticide poisoning; occupational diseases; paraquat; pesticide spraying; health hazards; risk factors; toxicology
Descriptors (secondary) literature survey; skin injuries; acute toxicity; hepatic damage; inhalation; skin absorption; pulmonary fibrosis; paronychia; aerosols; necrosis; blepharitis; conjunctivitis; keratitis; chemical burns; short-term exposure; long-term exposure; fatalities; safe working methods; irritants
Document type D - Periodical articles
Country / State or ProvinceFrance
Subject(s) Agriculture, fishing, animal husbandry
Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Heterocyclic compounds