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Document ID (ISN)103587
CIS number 04-634
ISSN - Serial title 0355-3140 - Scandinavian Journal of Work, Environment and Health
Year 2003
Convention or series no.
Author(s) Ellingsen D.G., Haug E., Gaarder P.I., Bast-Pettersen R., Thomassen Y.
Title Endocrine and immunologic markers in manganese alloy production workers
Bibliographic information June 2003, Vol.29, No.3, p.230-238. Illus. 24 ref.
Abstract One hundred randomly-selected male workers exposed to manganese were compared with one hundred unexposed male referents (matched for age) from similar process industries. The geometric mean of the exposed workers' urinary manganese concentration was 0.9 (range 0.1-126.3) nmol/mmol creatinine (Cr) versus 0.4 (range 0.1-13.1) nmol/mmol Cr for the referents. The mean duration of exposure to manganese was 20.0 (range 2.1-41.0) years. The geometric mean of the prolactin serum concentration was higher in the exposed subjects than in the referents (229 versus 197 mIU/L). Serum prolactin was associated with current exposure to soluble inhalable manganese, duration of exposure and smoking habits. The subjects with the longest duration of exposure to manganese or the highest current exposure to soluble inhalable manganese had a statistically significantly higher serum prolactin concentration than the referents, while smokers had a lower serum prolactin concentration than nonsmokers.
Descriptors (primary) manganese and compounds; alloys; serological reactions; endocrine effects; exposure; metalworking industry
Descriptors (secondary) antagonistic effects; manganese; male workers; smoking; respirable dust; creatinine excretion; case-control study; length of exposure; determination in blood; determination in urine; aerosols
Document type D - Periodical articles
Country / State or ProvinceNorway
Subject(s) Metal production and metalworking
Broad subject area(s) Chemical safety
Browse category(ies) Metalworking industry
Inorganic substances