|Document ID (ISN)||103550|
|ISSN - Serial title
||1351-0711 - Occupational and Environmental Medicine
|Convention or series no.
||Buzio L., De Palma G., Mozzoni P., Tondel M., Buzio C., Franchini I., Axelson O., Mutti A.
||Glutathione S-transferases M1-1 and T1-1 as risk modifiers for renal cell cancer associated with occupational exposure to chemicals
||Oct. 2003, Vol.60, No.10, p.789-793. 30 ref.
||This study investigates the possible interaction between occupational risk factors and genotype for glutathione S-transferases M1 and TI (GSTM 1 and GSTT 1) in renal cell cancer (RCC). One hundred patients with RCC and 200 outpatient controls were enrolled at Parma University Hospital. The polymorphisms of GSTM1 and GSTT1 were investigated by PCR; occupational history was collected by a structured questionnaire. Subjects with GSTM 1 present genotype showed higher risks for RCC, compared to GSTM 1 null subjects, if exposed to metals (OR 2.73) or pesticides (OR 3.46). The GSTT 1 present genotype also enhanced about twofold the risk of RCC among subjects exposed to solvents and pesticides, compared with those GSTT1 null. The results support the hypothesis that GSTM1 and GSTT1 polymorphisms can interact with several occupational exposures to significantly modify the risk of RCC among exposed subjects.
||transferases; genetic effects; chemical products; renal cancer
||Italy; metals; case-control study; solvents; hazard evaluation; pesticides
||D - Periodical articles
|Country / State or Province||Italy; Sweden|
||Toxic and dangerous substances
|Broad subject area(s)
Occupational medicine, epidemiology
||Diseases of the kidney and the urinary system
Genetic factors in reaction to exposures
Antifertility and prenatal effects