ILO Home
Go to the home page
Site map | Contact us Franšais | Espa˝ol

CISDOC database

Document ID (ISN)103364
CIS number 04-361
ISSN - Serial title 1232-1966 - AAEM - Annals of Agricultural and Environmental Medicine
Year 2003
Convention or series no.
Author(s) Hoffmann H.J., Iversen M., Brandslund I., Sigsgaard T., Omland ě., Oxvig C., Holmskov U., Bjermer L., Jensenius J.C., Dahl R.
Title Plasma C3d levels of young farmers correlate with respirable dust exposure levels during normal work in swine confinement buildings
Bibliographic information 2003, Vol.10, No.1, p.53-60. Illus. 48 ref.
Internet access http://www.aaem.pl/pdf/10053.pdf [in English]
04-0361.pdf [in English]
Abstract Work in swine confinement buildings may lead to an inflammatory response and may be associated with increased levels of acute phase proteins. This study compared the inflammatory response of former farm workers who had previously developed respiratory symptoms of wheeze, cough, tightness of the chest during work in swine confinement buildings and had stopped work because of these symptoms, with that of age-matched former farm workers who were known not to have developed such symptoms. Both groups were subjected to an experimental exposure in a swine confinement building for three hours. Complement activation and acute phase proteins were measured in blood samples and broncho-alveolar lavage. Plasma C3d levels correlated significantly with respirable dust. There was complement activation in response to respirable dust, more so among cases than in the control group. It is concluded that acute occupational exposure to organic dust containing endotoxin leads to a weak systemic inflammatory response.
Descriptors (primary) livestock rearing; swine; respiratory diseases; young persons; work in confined spaces; biological hazards; agriculture; respirable dust
Descriptors (secondary) airborne dust; Denmark; bacterial toxins; symptoms; dyspnoea; bronchopulmonary lavage; change of employment; inflammations; case-control study; serum complement; determination in blood; organic dust
Document type D - Periodical articles
Country / State or ProvinceDenmark; Norway
Subject(s) Agriculture, fishing, animal husbandry
Broad subject area(s) Industries and occupations
Biological hazards
Chemical safety
Browse category(ies) Diseases of the respiratory system (except for pneumoconiosis & similar)
Biological hazards
Livestock rearing
Confined spaces
Agriculture
Animal hazards