| Document ID (ISN) | 103223 |
| CIS number |
04-166 |
| ISBN(s) |
0-7176-2799-3 |
| Year |
2004 |
| Convention or series no. |
HSE Research Report RR 190
|
| Author(s) |
Loizou G., Sams C.
Health and Safety Executive |
| Title |
Inter-individual variability in the interpretation of biological monitoring guidance values |
| Bibliographic information |
HSE Books, P.O. Box 1999, Sudbury, Suffolk CO10 2WA, United Kingdom, 2004. iv, 48p. Illus. 94 ref. Price: GBP 10.00. Downloadable version free of charge. |
| Internet access |
http://www.hse.gov.uk/research/rrpdf/rr190.pdf [in English]
|
| Abstract |
The taking into account of individual factors in the setting of occupational exposure standards such as biological monitoring guidance values was studied by investigating the possibility of transferring in vitro measurements of variability in metabolism to the in vivo situation. Generic information on the activity of two enzyme systems considered important in the metabolism of industrial chemicals was investigated by using "probe" substrates. Variability in the activities of cytochromes P450 1A2 and 2E1, and the cytosolic glutathione transferases µ and θ were measured in human hepatocytes, hepatic microsomes and cytosols. Variability in the metabolism of styrene, a chemical of industrial importance, was also measured for comparison. The ability to use in vitro data to simulate in vivo variability was investigated by incorporating in vitro data into a physiologically-based pharmaco-kinetic (PBPK) model for styrene. The results show promise although further development is required to improve the yields of viable cells. |
| Descriptors (primary) |
individual variables; biological threshold limits; reliability; United Kingdom |
| Descriptors (secondary) |
report; enzyme activity determination; in vitro experiments; styrene |
| Document type |
E - Books, reports, proceedings |
| Country / State or Province | United Kingdom |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
Chemical safety
|
| Browse category(ies) |
Occupational exposure limits
|
