|Document ID (ISN)||103165|
|Convention or series no.
||Fahrig R., Görlitz B.D., Preiß A.
Bundesanstalt für Arbeitsschutz und Arbeitsmedizin
||Genotoxic effects of 3,3'-dihydroxybenzidine including stability investigations
||Prüfung der genotoxischen Wirkung von 3,3'-Dihydroxybenzidin einschließlich Untersuchungen zur Stabilität [in German]|
||Wirtschaftsverlag NW, Postfach 10 11 10, 27511 Bremerhaven, Germany, 2003. 196p. Illus. 7 ref. Price: EUR 17.00.
||In this study, the mutagenic activity of 3,3'-dihydroxybenzidine in various biological systems was examined. 3,3'-dihydroxybenzidine induced isolated mutations in bacteria as well as genetic mutations and chromosomal aberrations in cell cultures (V79). In a UDS test (non-programmed DNA synthesis) on rat hepatocytes, toxic effects were observed on the hepatocytes, but there was no increase in DNA synthesis. There was no evidence of 3,3'-dihydroxybenzidine toxicity in a micronucleus test on mice. The stability of 3,3'-dihydroxybenzidine in acetonitrile and in aqueous and organic solvent mixtures was also examined. In the latter case, degradation was observed in both buffered and unbuffered mixtures.
||mutagenic effects; stability; 3,3'-dihydroxybenzidine
||toxic effects; chromosome changes; in vitro experiments; animal experiments
||E - Books, reports, proceedings
|Country / State or Province||Germany|
||Toxic and dangerous substances
|Broad subject area(s)
||Antifertility and prenatal effects
Genetic factors in reaction to exposures