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Document ID (ISN)103165
CIS number 04-165
ISBN(s) 3-89701-932-9
Year 2003
Convention or series no. Fb 975
Author(s) Fahrig R., Görlitz B.D., Preiß A.
Bundesanstalt für Arbeitsschutz und Arbeitsmedizin
Title Genotoxic effects of 3,3'-dihydroxybenzidine including stability investigations
Original title Prüfung der genotoxischen Wirkung von 3,3'-Dihydroxybenzidin einschließlich Untersuchungen zur Stabilität [in German]
Bibliographic information Wirtschaftsverlag NW, Postfach 10 11 10, 27511 Bremerhaven, Germany, 2003. 196p. Illus. 7 ref. Price: EUR 17.00.
Abstract In this study, the mutagenic activity of 3,3'-dihydroxybenzidine in various biological systems was examined. 3,3'-dihydroxybenzidine induced isolated mutations in bacteria as well as genetic mutations and chromosomal aberrations in cell cultures (V79). In a UDS test (non-programmed DNA synthesis) on rat hepatocytes, toxic effects were observed on the hepatocytes, but there was no increase in DNA synthesis. There was no evidence of 3,3'-dihydroxybenzidine toxicity in a micronucleus test on mice. The stability of 3,3'-dihydroxybenzidine in acetonitrile and in aqueous and organic solvent mixtures was also examined. In the latter case, degradation was observed in both buffered and unbuffered mixtures.
Descriptors (primary) mutagenic effects; stability; 3,3'-dihydroxybenzidine
Descriptors (secondary) toxic effects; chromosome changes; in vitro experiments; animal experiments
Document type E - Books, reports, proceedings
Country / State or ProvinceGermany
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Antifertility and prenatal effects
Aromatic amines
Genetic factors in reaction to exposures