|Document ID (ISN)||102791|
|ISSN - Serial title
||0003-4878 - Annals of Occupational Hygiene
|Convention or series no.
||McCanlies E., Landsittel D.P., Yucesoy B., Vallyathan V., Luster M.L., Sharp D.S.
||Significance of genetic information in risk assessment and individual classification using silicosis as a case model
||June 2002, vol.46, No.4, p.375-381. Illus. 21 ref.
||This study addresses how, given a known exposure, genetic information affects the characterization of risk groups. The probability of developing silicosis in a population of coal miners in Turkey was estimated using logistic regression on the basis of lung tissue samples from autopsy. This probability was then used to construct predicted risk deciles, first for a model with occupational exposure only, and later for a model containing occupational exposure and genetic main effects and interactions. The results indicate that genetic information plays a valuable role in effectively characterizing risk groups and mechanisms of diseases in a substantial proportion of the population. However, in the case of fibrotic lung disease caused by silica exposure, information about the presence or absence of the minor variants of interleukin-1α, interleukin-1 receptor antagonist and tumour necrosis factor-α is unlikely to be a useful tool for individual classification.
||individual variables; DNA; silica; exposure; silicosis; hazard evaluation; epidemiology
||interleukins; pulmonary fibrosis; prediction formulae; mathematical models; high-risk groups
||D - Periodical articles
|Country / State or Province||Turkey; USA|
||Dust, aerosols and related diseases
|Broad subject area(s)
Occupational medicine, epidemiology