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CISDOC database

Document ID (ISN)102791
CIS number 03-1614
ISSN - Serial title 0003-4878 - Annals of Occupational Hygiene
Year 2002
Convention or series no.
Author(s) McCanlies E., Landsittel D.P., Yucesoy B., Vallyathan V., Luster M.L., Sharp D.S.
Title Significance of genetic information in risk assessment and individual classification using silicosis as a case model
Bibliographic information June 2002, vol.46, No.4, p.375-381. Illus. 21 ref.
Abstract This study addresses how, given a known exposure, genetic information affects the characterization of risk groups. The probability of developing silicosis in a population of coal miners in Turkey was estimated using logistic regression on the basis of lung tissue samples from autopsy. This probability was then used to construct predicted risk deciles, first for a model with occupational exposure only, and later for a model containing occupational exposure and genetic main effects and interactions. The results indicate that genetic information plays a valuable role in effectively characterizing risk groups and mechanisms of diseases in a substantial proportion of the population. However, in the case of fibrotic lung disease caused by silica exposure, information about the presence or absence of the minor variants of interleukin-1α, interleukin-1 receptor antagonist and tumour necrosis factor-α is unlikely to be a useful tool for individual classification.
Descriptors (primary) individual variables; DNA; silica; exposure; silicosis; hazard evaluation; epidemiology
Descriptors (secondary) interleukins; pulmonary fibrosis; prediction formulae; mathematical models; high-risk groups
Document type D - Periodical articles
Country / State or ProvinceTurkey; USA
Subject(s) Dust, aerosols and related diseases
Broad subject area(s) Chemical safety
Occupational medicine, epidemiology
Browse category(ies) Pneumoconioses
Risk evaluation
Epidemiology