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CISDOC database
| Document ID (ISN) | 102738 |
| CIS number |
03-1744 |
| ISSN - Serial title |
1542-8117 - AIHA Journal |
| Year |
2003 |
| Convention or series no. |
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| Author(s) |
Boucher R., Hanna C., Rusch G.M., Stidham D., Swan E., Vazquez M. |
| Title |
Hepatotoxicity associated with overexposure to 1,1-dichloro-2,2,2-trifluoroethane (HCFC-123) |
| Bibliographic information |
Jan.-Feb. 2003, Vol.64, No.1, p.68-79. Illus. 12 ref. |
| Abstract |
When 1,1-dichloro-2,2,2-trifluoroethane (HCFC-123) was introduced as a precision cleaning agent in a controlled operation, marked elevations in serum alanine transaminase and serum aspartase transaminase were noted in exposed workers. Personal and area samples collected after the liver abnormalities were identified ranged from 5-12ppm. Exposure data were not available for the period when the abnormalities are suspected to have developed. Modeling using the entire building as a homogenous box estimated 8-h time-weighted average (TWA) exposures of 10-35ppm. Modeled estimates of work area and air exchange rates indicated that exposed workers in the degreaser area could have experienced peak levels of 635-2100ppm (8-hour TWA). |
| Descriptors (primary) |
hepatotoxic effects; degreasing; 1,1-dichloro-2,2,2-trifluoroethane; exposure evaluation |
| Descriptors (secondary) |
personal sampling; mathematical models; determination in air; transaminases |
| Document type |
D - Periodical articles |
| Country / State or Province | USA |
| Subject(s) |
Toxic and dangerous substances
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| Broad subject area(s) |
Chemical safety
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| Browse category(ies) |
Exposure evaluation
Halogenated hydrocarbons
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