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CISDOC database

Document ID (ISN)102737
CIS number 03-1779
ISSN - Serial title 0105-1873 - Contact Dermatitis
Year 2003
Convention or series no.
Author(s) Korinth G., G÷en T., Lakemeyer M., Broding H.C., Drexler H.
Title Skin strain and its influence on systemic exposure to a glycol ether in offset printing workers
Bibliographic information Nov. 2003, Vol.49, No.5, p.248-254. Illus. 31 ref.
Abstract The aim of this study was to show whether systemic exposure to glycol ether is higher among printing workers with skin lesions. 28 male printers exposed to 2-(2-butoxyethoxy)ethanol (BEE) were interviewed on their workplace exposure by means of a standardized questionnaire. The systemic exposure was determined by biological monitoring of the main metabolite of BEE (butoxyethoxyacetic acid, BEAA) in urine. Furthermore, a clinical examination of the skin was also carried out, together with measurements of transepidermal water loss, capacitance and skin surface pH. Erythema and scaliness were the most important factors showing an effect on dermal absorption. The mean urinary BEAA excretions for printers with skin lesions on the hands were higher (20.62mg/L for scaliness and 14.40mg/L for erythema) compared to levels for printers without detectable skin lesions (12.08mg/L for scaliness and 13.03mg/L for erythema).
Descriptors (primary) diethylene glycol butyl ether; skin absorption; organic solvents; skin diseases; offset printing
Descriptors (secondary) erythema; exposure evaluation; determination in urine; urinary metabolites; questionnaire survey
Document type D - Periodical articles
Country / State or ProvinceGermany
Subject(s) Paper-making and printing
Broad subject area(s) Chemical safety
Browse category(ies) Skin diseases
Glycol ethers
Printing, photography and photocopying industry