|Document ID (ISN)||102704|
|Convention or series no.
||ECETOC JACC No.43
||sec-Butanol (CAS No. 78-92-2)
||European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC), Avenue E. Van Nieuwenhuyse 4, Bte. 6, 1160 Bruxelles, Belgium, Dec. 2003. 76p. Illus. Approx. 200 ref.
||Conclusions of this criteria document: acute toxicity of sec-butanol (sBA; also: sec-butyl alcohol) is low in laboratory animals. It is non-irritant to rabbit skin, but is severely irritant to the eye. It is not a skin sensitizer in guinea pigs. sBA is not genotoxic and there is no concern for a carcinogenic potential. sBA showed some foetotoxicity in laboratory animals at high concentrations. In humans, no adverse systemic effects associated with acute or repeated exposure to sBA have been reported. As sBA is volatile, high exposure levels may result in acute central nervous system effects, including headache and dizziness. sBA, after transformation to methyl ethyl ketone, may potentiate the neurotoxicity of certain neurotoxic ketones; such effects, however, have not been reported so far.
||sec-butyl alcohol; volatile substances; toxicology
||neurotoxic effects; butanone; criteria document; vertigo; animal experiments; migraine
||B - Chemical safety information sheets
|Country / State or Province||Belgium|
||Toxic and dangerous substances
|Broad subject area(s)