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Document ID (ISN)102704
CIS number 03-1528
Year 2003
Convention or series no. ECETOC JACC No.43
Title sec-Butanol (CAS No. 78-92-2)
Bibliographic information European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC), Avenue E. Van Nieuwenhuyse 4, Bte. 6, 1160 Bruxelles, Belgium, Dec. 2003. 76p. Illus. Approx. 200 ref.
Abstract Conclusions of this criteria document: acute toxicity of sec-butanol (sBA; also: sec-butyl alcohol) is low in laboratory animals. It is non-irritant to rabbit skin, but is severely irritant to the eye. It is not a skin sensitizer in guinea pigs. sBA is not genotoxic and there is no concern for a carcinogenic potential. sBA showed some foetotoxicity in laboratory animals at high concentrations. In humans, no adverse systemic effects associated with acute or repeated exposure to sBA have been reported. As sBA is volatile, high exposure levels may result in acute central nervous system effects, including headache and dizziness. sBA, after transformation to methyl ethyl ketone, may potentiate the neurotoxicity of certain neurotoxic ketones; such effects, however, have not been reported so far.
Descriptors (primary) sec-butyl alcohol; volatile substances; toxicology
Descriptors (secondary) neurotoxic effects; butanone; criteria document; vertigo; animal experiments; migraine
Document type B - Chemical safety information sheets
Country / State or ProvinceBelgium
Subject(s) Toxic and dangerous substances
Broad subject area(s)
Browse category(ies) Alcohols