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Document ID (ISN)102702
CIS number 03-1526
Year 2003
Convention or series no. ECETOC JACC No.41
Title n-Butanol (CAS No.71-36-3)
Bibliographic information European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC), Avenue E. Van Nieuwenhuyse 4, Bte. 6, 1160 Bruxelles, Belgium, Dec. 2003. 116p. Illus. Approx. 390 ref.
Abstract Conclusions of this criteria document: n-butanol (nBA; also: butyl alcohol) is readily absorbed through the lungs of humans and laboratory animals and can also penetrate the skin. It is of low toxicity in animals when administrated by gavage, inhalation or application to the skin. The typical effect of exposure to high doses of nBA is a transient, depression (narcosis) of the central nervous system. Specific neurotoxicity is not observed. Specific target organs and selective toxicity have not been identified. nBA is not genotoxic and there is no concern for carcinogenic potential. It showed some foetotoxicity in laboratory animals at high concentrations. Earlier reports describing neurotoxicity and hearing loss in workers exposed to nBA have not been substantiated. Toxic effects in humans: slightly to moderately irritant to the skin on prolonged contact, and moderately irritant to the eyes.
Descriptors (primary) toxicology; butyl alcohol
Descriptors (secondary) irritants; skin absorption; criteria document; narcotic effects; animal experiments
Document type B - Chemical safety information sheets
Country / State or ProvinceBelgium
Subject(s) Toxic and dangerous substances
Broad subject area(s)
Browse category(ies) Alcohols