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Document ID (ISN)102582
CIS number 03-1772
ISSN - Serial title 1076-2752 - Journal of Occupational and Environmental Medicine
Year 2004
Convention or series no.
Author(s) Markowitz S.B., Levin K.
Title Continued epidemic of bladder cancer in workers exposed to ortho-toluidine in a chemical factory
Bibliographic information Feb. 2004, Vol.46, No.2, p.154-160. Illus. 15 ref.
Abstract Ortho-toluidine (o-toluidine), an aromatic amine, is classified by the International Agency for Research on Cancer as a probable human carcinogen. A cohort study published in 1991 reported a 6.5-fold excess incidence of bladder cancer in a US chemical plant that used o-toluidine. This article reports 19 additional cases of bladder cancer among workers in this cohort, yielding a total of 34 cases of bladder cancer in the cohort to date. The number of bladder cancers diagnosed in the recent period has increased. The timing of onset of exposure to o-toluidine of numerous cases of bladder cancer after 1968, and especially 1975, suggests that occupational exposures other than o-toluidine were probably not responsible for the observed excess bladder cancer. This study further supports the bladder carcinogenicity of o-toluidine.
Descriptors (primary) carcinogens; bladder tumour; o-toluidine; chemical industry
Descriptors (secondary) USA; IARC; frequency rates; cohort study; long-term study; diagnosis
Document type D - Periodical articles
Country / State or ProvinceUSA
Subject(s) Chemicals, plastics and rubber
Broad subject area(s) Chemical safety
Browse category(ies) Diseases of the kidney and the urinary system
Aromatic amines
Chemical industry