|Document ID (ISN)||102503|
|ISSN - Serial title
||0271-3586 - American Journal of Industrial Medicine
|Convention or series no.
||Başaran N., Shubair M., ▄ndeğer ▄., Kars A.
||Monitoring DNA damage in foundry and pottery workers exposed to silica by the alkaline comet assay
||June 2003, Vol.43, No.6, p.602-610. 43 ref.
||Workers in the foundry and pottery industries are exposed to a mixture of chemicals including silica, a substance widely suspected of causing genetic alterations. To investigate the potential hazard associated with the occupational exposure to silica, DNA damages in the peripheral lymphocytes of 30 foundry and 22 pottery workers were examined using the alkaline gel electrophoresis or comet assay method, and compared with 52 healthy subjects with no history of occupational exposure to silica or other chemicals. The DNA damage observed in the lymphocytes of both foundry and pottery workers was significantly higher than that among controls. DNA damage was also caused by cigarette smoking, since the damage observed in smoking silica-exposed workers compared with the non-smoking workers was significantly higher.
||DNA; silica; foundries; pottery industry; risk factors
||lymphocytes; Turkey; smoking; immunoelectrophoresis; experimental pathology; genetic effects; case-control study
||D - Periodical articles
|Country / State or Province||Turkey|
||Mines and quarries
|Broad subject area(s)
||Foundries, metalcasting and forging operations
Genetic factors in reaction to exposures
Glass, pottery and related materials